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Anti-eIF3K Antibody

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产品名称: Anti-eIF3K Antibody
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Anti-eIF3K Antibody


Anti-eIF3K Antibody  的详细介绍
Name: Anti-eIF3K Antibody
See all eIF3K primary antibodies
Description: Rabbit polyclonal antibody to eIF3K
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 133 (Q9UBQ5) of EIF3K
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity purified by Protein A.
Formulation: Supplied in 1XPBS, 1%BSA, 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Tissue Specificity: Ubiquitous, with the highest levels of expression in brain, testis and kidney.
Sequence Similarities: Belongs to the eIF-3 subunit K family.
Cellular Location: Nucleus. Cytoplasm.
Database Links:
  • Entrez Gene: 27335 Human
  • Omim: 609596 Human
  • SwissProt: Q9UBQ5 Human
  • Unigene: 314359 Human
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    Synonyms:
  • ARG134 Antibody
  • eIF 3 p25 Antibody
  • eIF 3 p28 Antibody
  • eIF-3 p25 Antibody
  • eIF-3 p28 Antibody
  • EIF3-p28 Antibody
  • eIF3K Antibody
  • EIF3K_HUMAN Antibody
  • EIF3S12 Antibody
  • Eukaryotic translation initiation factor 3 subunit 12 Antibody
  • Eukaryotic translation initiation factor 3 subunit K Antibody
  • HSPC029 Antibody
  • M9 Antibody
  • MSTP001 Antibody
  • Muscle specific gene M9 protein Antibody
  • Muscle-specific gene M9 protein Antibody
  • PLAC 24 Antibody
  • PLAC-24 Antibody
  • PLAC24 Antibody
  • PRO1474 Antibody
  • PTD001 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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