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Anti-EIF3I Antibody

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产品名称: Anti-EIF3I Antibody
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简单介绍

Anti-EIF3I Antibody


Anti-EIF3I Antibody  的详细介绍
Name: Anti-EIF3I Antibody
See all EIF3I primary antibodies
Description: Rabbit polyclonal antibody to EIF3I
Specificity: The antibody detects endogenous levels of total EIF3I protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein of human EIF3I
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Sequence Similarities: Belongs to the eIF-3 subunit I family.
Post-Translational Modification: Phosphorylated by TGF-beta type II receptor.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 8668?Human
  • Omim: 603911?Human
  • SwissProt: Q13347?Human
  • Unigene: 530096?Human
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    Synonyms:
  • eIF-3-beta Antibody
  • eIF3 beta Antibody
  • eIF3 p36 Antibody
  • eIF3-beta Antibody
  • eIF3-p36 Antibody
  • eIF3i Antibody
  • EIF3I_HUMAN Antibody
  • EIF3S2 Antibody
  • EIF3S2, formerly Antibody
  • Eukaryotic translation initiation factor 3 subunit 2 Antibody
  • Eukaryotic translation initiation factor 3 subunit 2 beta Antibody
  • Eukaryotic translation initiation factor 3 subunit I Antibody
  • eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD Antibody
  • eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa Antibody
  • eukaryotic translation initiation factor 3, subunit 2, formerly Antibody
  • eukaryotic translation initiation factor 3, subunit I Antibody
  • Predicted protein of HQ2242 Antibody
  • PRO2242 Antibody
  • TGF beta receptor interacting protein 1 Antibody
  • TGF-beta receptor-interacting protein 1 Antibody
  • TGFbeta receptor interacting protein 1 Antibody
  • TGFbeta receptor-interacting protein 1 Antibody
  • TRIP 1 Antibody
  • TRIP-1 Antibody
  • TRIP1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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