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Anti-EIF3F Antibody

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产品名称: Anti-EIF3F Antibody
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简单介绍

Anti-EIF3F Antibody


Anti-EIF3F Antibody  的详细介绍
Name: Anti-EIF3F Antibody
See all EIF3F primary antibodies
Description: Rabbit polyclonal antibody to EIF3F
Specificity: The antibody detects endogenous levels of total EIF3F protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Fusion protein corresponding to residues near the C terminal of human eukaryotic translation initiation factor 3, subunit F
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Sequence Similarities: Belongs to the eIF-3 subunit F family.
Post-Translational Modification: Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 8665?Human
  • Entrez Gene: 66085?Mouse
  • Omim: 603914?Human
  • SwissProt: O00303?Human
  • SwissProt: Q9DCH4?Mouse
  • Unigene: 516023?Human
  • Unigene: 182962?Mouse
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    Synonyms:
  • Deubiquitinating enzyme eIF3f Antibody
  • eIF 3 epsilon Antibody
  • eIF-3-epsilon Antibody
  • eIF3 p47 Antibody
  • eIF3 p47 subunit Antibody
  • eIF3-epsilon Antibody
  • eIF3-p47 Antibody
  • EIF3F Antibody
  • EIF3F_HUMAN Antibody
  • EIF3S5 Antibody
  • EIF3S5, formerly Antibody
  • Eukaryotic translation initiation factor 3 subunit 5 Antibody
  • Eukaryotic translation initiation factor 3 subunit 5, formerly Antibody
  • Eukaryotic translation initiation factor 3 subunit F Antibody
  • eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD) Antibody
  • eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa Antibody
  • eukaryotic translation initiation factor 3, subunit F Antibody
  • translation initiation factor 3 47 kda subunit Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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