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Anti-EIF3E Antibody

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产品名称: Anti-EIF3E Antibody
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简单介绍

Anti-EIF3E Antibody


Anti-EIF3E Antibody  的详细介绍
Name: Anti-EIF3E Antibody
See all EIF3E primary antibodies
Description: Rabbit polyclonal antibody to EIF3E.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human EIF3E.
Protein Length: 445
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).
Tissue Specificity: Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
Sequence Similarities: Belongs to the eIF-3 subunit E family.
Cellular Location: Cytoplasm. Nucleus > PML body.
Database Links:
  • Entrez Gene: 3646?Human
  • Entrez Gene: 16341?Mouse
  • Entrez Gene: 299872?Rat
  • Omim: 602210?Human
  • SwissProt: P60228?Human
  • SwissProt: P60229?Mouse
  • SwissProt: Q641X8?Rat
  • Unigene: 405590?Human
  • Unigene: 289992?Mouse
  • Unigene: 98547?Rat
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    Synonyms:
  • eIF-3 p48 Antibody
  • eIF3e Antibody
  • EIF3E_HUMAN Antibody
  • EIF3S6 Antibody
  • eIFe Antibody
  • Eukaryotic translation initiation factor 3 subunit 6 Antibody
  • Eukaryotic translation initiation factor 3 subunit E Antibody
  • eukaryotic translation initiation factor 3, subunit 6 (48kD) Antibody
  • INT6 Antibody
  • mammary tumor-associated protein INT6 Antibody
  • murine mammary tumor integration site 6 (oncogene homolog) Antibody
  • Viral integration site protein INT-6 homolog Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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