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Anti-EIF3A Antibody

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产品名称: Anti-EIF3A Antibody
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简单介绍

Anti-EIF3A Antibody


Anti-EIF3A Antibody  的详细介绍
Name: Anti-EIF3A Antibody
See all EIF3A primary antibodies
Description: Rabbit polyclonal antibody to EIF3A.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human EIF3A.
Protein Length: 1382
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
Sequence Similarities: Belongs to the eIF-3 subunit A family.
Post-Translational Modification: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 8661?Human
  • Entrez Gene: 13669?Mouse
  • Entrez Gene: 292148?Rat
  • Omim: 602039?Human
  • SwissProt: Q14152?Human
  • SwissProt: P23116?Mouse
  • SwissProt: Q1JU68?Rat
  • Unigene: 523299?Human
  • Unigene: 713331?Human
  • Unigene: 2238?Mouse
  • Unigene: 482533?Mouse
  • Unigene: 1644?Rat
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    Synonyms:
  • centrosomin homolog Antibody
  • cytoplasmic protein p167 Antibody
  • eIF 3 theta Antibody
  • eIF-3-theta Antibody
  • EIF3 Antibody
  • eIF3 p167 Antibody
  • eIF3 p170 Antibody
  • eIF3 p180 Antibody
  • EIF3 p180 subunit Antibody
  • eIF3 p185 Antibody
  • eIF3 theta Antibody
  • eIF3A Antibody
  • EIF3A_HUMAN Antibody
  • EIF3S10 Antibody
  • Eukaryotic translation initiation factor 3 subunit 10 Antibody
  • eukaryotic translation initiation factor 3 subunit 10 (theta 150 170kD) Antibody
  • eukaryotic translation initiation factor 3 subunit 10 (theta 170kD) Antibody
  • eukaryotic translation initiation factor 3 subunit 10 170kDa Antibody
  • eukaryotic translation initiation factor 3 subunit 10 theta 150 170kDa Antibody
  • Eukaryotic translation initiation factor 3 subunit A Antibody
  • OTTHUMP00000020589 Antibody
  • P167 Antibody
  • p180 Antibody
  • p185 Antibody
  • TIF32 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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