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Anti-Eg5 (P923) Antibody

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产品名称: Anti-Eg5 (P923) Antibody
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Anti-Eg5 (P923) Antibody


Anti-Eg5 (P923) Antibody  的详细介绍
Name: Anti-Eg5 (P923) Antibody
See all Eg5 primary antibodies
Description: Rabbit polyclonal antibody to Eg5 (P923)
Specificity: Eg5 (P923) pAb detects endogenous levels of Eg5 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 900-950 of Human Eg5.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 119 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
Involvement in Disease: Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.
Sequence Similarities: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
Post-Translational Modification: Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
Cellular Location: Cytoplasm. Cytoplasm > Cytoskeleton > Spindle pole.
Database Links:
  • Entrez Gene: 3832?Human
  • Entrez Gene: 16551?Mouse
  • Omim: 148760?Human
  • SwissProt: P52732?Human
  • SwissProt: Q6P9P6?Mouse
  • Unigene: 8878?Human
  • Unigene: 42203?Mouse
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    Synonyms:
  • Eg5 Antibody
  • HKSP Antibody
  • KIF11 Antibody
  • KIF11_HUMAN Antibody
  • Kinesin family member 11 Antibody
  • Kinesin like protein 1 Antibody
  • Kinesin-like protein 1 Antibody
  • Kinesin-like protein KIF11 Antibody
  • Kinesin-like spindle protein HKSP Antibody
  • Kinesin-related motor protein Eg5 Antibody
  • KNSL1 Antibody
  • MCLMR Antibody
  • Thyroid receptor-interacting protein 5 Antibody
  • TR-interacting protein 5 Antibody
  • TRIP-5 Antibody
  • TRIP5 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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