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Anti-EFP (D222) Antibody

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产品名称: Anti-EFP (D222) Antibody
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Anti-EFP (D222) Antibody


Anti-EFP (D222) Antibody  的详细介绍
Name: Anti-EFP (D222) Antibody
See all EFP primary antibodies
Description: Rabbit polyclonal antibody to EFP (D222)
Specificity: EFP (D222) pAb detects endogenous levels of EFP protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 360-418 of Human EFP.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 71 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
Tissue Specificity: Expressed in breast tumors (at protein level). Ubiquitous.
Post-Translational Modification: Auto-ISGylated.
Cellular Location: Cytoplasm.

Colocalized with DDX58 at cytoplasmic perinuclear bodies.
Database Links:
  • Entrez Gene: 7706?Human
  • Entrez Gene: 217069?Mouse
  • Entrez Gene: 494338?Rat
  • Omim: 600453?Human
  • SwissProt: Q14258?Human
  • SwissProt: Q61510?Mouse
  • Unigene: 528952?Human
  • Unigene: 248445?Mouse
  • Unigene: 34382?Rat
    		•
    Synonyms:
  • E3 ubiquitin/ISG15 ligase TRIM25 Antibody
  • EFP Antibody
  • Estrogen responsive finger protein Antibody
  • Estrogen-responsive finger protein Antibody
  • RING finger protein 147 Antibody
  • RNF 147 Antibody
  • RNF147 Antibody
  • TRI25 Antibody
  • TRI25_HUMAN Antibody
  • TRIM 25 Antibody
  • TRIM25 Antibody
  • Tripartite motif containing 25 Antibody
  • Tripartite motif containing protein 25 Antibody
  • Tripartite motif protein TRIM25 Antibody
  • Tripartite motif-containing protein 25 Antibody
  • Tripartite motifcontaining25 Antibody
  • Ubiquitin/ISG15-conjugating enzyme TRIM25 Antibody
  • Z147 Antibody
  • Zinc finger protein 147 Antibody
  • Zinc finger protein 147 (estrogen responsive finger protein) Antibody
  • Zinc finger protein-147 Antibody
  • ZNF 147 Antibody
  • ZNF147 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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