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Anti-EFNA1 Antibody

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产品名称: Anti-EFNA1 Antibody
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简单介绍

Anti-EFNA1 Antibody


Anti-EFNA1 Antibody  的详细介绍
Name: Anti-EFNA1 Antibody
See all EFNA1 primary antibodies
Description: Goat polyclonal antibody to EFNA1.
Applications: ELISA, WB
Reactivity: Mouse, Rat
Immunogen: Synthetic peptide corresponding to Human EFNA1 (internal region).
Sequence: C-KVTVSGKITHSP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
Sequence Similarities: Belongs to the ephrin family.
Post-Translational Modification: Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 13636 Mouse
  • Entrez Gene: 94268 Rat
  • SwissProt: P52793 Mouse
  • SwissProt: P97553 Rat
  • Unigene: 15675 Mouse
  • Unigene: 8427 Rat
    		•
    Synonyms:
  • B61 Antibody
  • ECKLG Antibody
  • EFL 1 Antibody
  • EFL1 Antibody
  • EFNA 1 Antibody
  • Efna1 Antibody
  • EFNA1_HUMAN Antibody
  • EPH related receptor tyrosine kinase ligand 1 Antibody
  • EPH-related receptor tyrosine kinase ligand 1 Antibody
  • Ephrin A1 Antibody
  • Ephrin-A1 Antibody
  • Ephrin-A1, secreted form Antibody
  • EphrinA1 Antibody
  • EPLG 1 Antibody
  • EPLG1 Antibody
  • Immediate early response protein B61 Antibody
  • LERK 1 Antibody
  • LERK-1 Antibody
  • LERK1 Antibody
  • Ligand of eph related kinase 1 Antibody
  • OTTHUMP00000033242 Antibody
  • OTTHUMP00000033271 Antibody
  • secreted form Antibody
  • TNF alpha-induced protein 4 Antibody
  • TNFAIP 4 Antibody
  • TNFAIP4 Antibody
  • Tumor necrosis factor alpha induced protein 4 Antibody
  • Tumor necrosis factor alpha-induced protein 4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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