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Anti-EFCAB4B Antibody

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产品名称: Anti-EFCAB4B Antibody
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简单介绍

Anti-EFCAB4B Antibody


Anti-EFCAB4B Antibody  的详细介绍
Name: Anti-EFCAB4B Antibody
See all EFCAB4B primary antibodies
Description: Rabbit polyclonal antibody to EFCAB4B
Applications: E, WB, IHC
Reactivity: Human, Mouse
Immunogen: Raised against a 14 amino acid peptide near the carboxy terminus of human EFCAB4B.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).
Sequence Similarities: Belongs to the EFCAB4 family.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 84766?Human
  • Entrez Gene: 381812?Mouse
  • Omim: 614178?Human
  • SwissProt: Q9BSW2?Human
  • SwissProt: Q3UP38?Mouse
  • Unigene: 504534?Human
  • Unigene: 296093?Mouse
    		•
    Synonyms:
  • Calcium release-activated calcium channel regulator 2A Antibody
  • CRAC channel regulator 2A Antibody
  • CRACR2A Antibody
  • EF hand calcium binding domain 4B Antibody
  • EF hand calcium binding domain containing protein 4B Antibody
  • EF-hand calcium-binding domain-containing protein 4B Antibody
  • EFC4B_HUMAN Antibody
  • EFCAB 4B Antibody
  • EFCAB4B Antibody
  • FLJ33805 Antibody
  • MGC4266 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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