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Anti-EEF2K Antibody

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产品名称: Anti-EEF2K Antibody
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简单介绍

Anti-EEF2K Antibody


Anti-EEF2K Antibody  的详细介绍
Name: Anti-EEF2K Antibody
See all EEF2K primary antibodies
Description: Rabbit polyclonal antibody to EEF2K.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human EEF2K.
Protein Length: 725
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Sequence Similarities: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
Post-Translational Modification: Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
Database Links:
  • Entrez Gene: 29904?Human
  • Entrez Gene: 13631?Mouse
  • Entrez Gene: 25435?Rat
  • Omim: 606968?Human
  • SwissProt: O00418?Human
  • SwissProt: O08796?Mouse
  • SwissProt: P70531?Rat
  • Unigene: 498892?Human
  • Unigene: 25997?Mouse
  • Unigene: 361795?Mouse
  • Unigene: 10958?Rat
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    Synonyms:
  • C86191 Antibody
  • Calcium/calmodulin dependent eukaryotic elongation factor 2 Antibody
  • Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase Antibody
  • Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase Antibody
  • Calmodulin dependent protein kinase III Antibody
  • cb365 Antibody
  • EC 2.7.11.20 Antibody
  • eEF 2 kinase Antibody
  • eEF 2K Antibody
  • eEF-2 kinase Antibody
  • eEF-2K Antibody
  • EEF2K Antibody
  • EEF2K protein Antibody
  • EF2K_HUMAN Antibody
  • Elongation factor 2 kinase Antibody
  • Eukaryotic elongation factor 2 kinase Antibody
  • fa04b08 Antibody
  • HSU93850 Antibody
  • kinase eEF2K Antibody
  • MGC45041 Antibody
  • SMEF2K Antibody
  • wu:fa04b08 Antibody
  • zgc:100973 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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