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Anti-EEF2 Antibody

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产品名称: Anti-EEF2 Antibody
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Anti-EEF2 Antibody


Anti-EEF2 Antibody  的详细介绍
Name: Anti-EEF2 Antibody
See all EEF2 primary antibodies
Description: Rabbit polyclonal antibody to EEF2
Specificity: The antibody detects endogenous level of total EEF2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human EEF2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Involvement in Disease: Spinocerebellar ataxia 26: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
Sequence Similarities: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Post-Translational Modification: Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
Cellular Location: Cytoplasm. Nucleus.

Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product.
Database Links:
  • Entrez Gene: 1938?Human
  • Entrez Gene: 13629?Mouse
  • Entrez Gene: 29565?Rat
  • Omim: 130610?Human
  • SwissProt: P13639?Human
  • SwissProt: P58252?Mouse
  • SwissProt: P05197?Rat
  • Unigene: 515070?Human
  • Unigene: 326799?Mouse
  • Unigene: 379638?Mouse
  • Unigene: 482883?Mouse
  • Unigene: 55145?Rat
    		•
    Synonyms:
  • EEF 2 Antibody
  • EEF2 Antibody
  • EF-2 Antibody
  • EF2 Antibody
  • EF2_HUMAN Antibody
  • Elongation factor 2 Antibody
  • Eukaryotic translation elongation factor 2 Antibody
  • Polypeptidyl tRNA translocase Antibody
  • SCA26 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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