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Anti-Dyrk1A Antibody

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产品名称: Anti-Dyrk1A Antibody
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Anti-Dyrk1A Antibody


Anti-Dyrk1A Antibody  的详细介绍
Name: Anti-Dyrk1A Antibody
See all Dyrk1A primary antibodies
Description: Rabbit polyclonal antibody to Dyrk1A
Specificity: Dyrk1A Polyclonal Antibody detects endogenous levels of Dyrk1A protein.
Applications: WB, IHC, IF, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the N-terminal region of human Dyrk1A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Tissue Specificity: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Involvement in Disease: Mental retardation, autosomal dominant 7: A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Post-Translational Modification: Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).
Cellular Location: Nucleus. Nucleus speckle.
Database Links:
  • Entrez Gene: 1859?Human
  • Entrez Gene: 13548?Mouse
  • Entrez Gene: 25255?Rat
  • Omim: 600855?Human
  • SwissProt: Q13627?Human
  • SwissProt: Q61214?Mouse
  • SwissProt: Q63470?Rat
  • Unigene: 368240?Human
  • Unigene: 310973?Mouse
  • Unigene: 9354?Rat
    		•
    Synonyms:
  • Dual specificity tyrosine phosphorylation regulated kinase Antibody
  • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A Antibody
  • Dual specificity tyrosine phosphorylation regulated kinase 1 Antibody
  • Dual specificity tyrosine phosphorylation regulated kinase 1A Antibody
  • Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody
  • Dual specificity YAK 1 related kinase Antibody
  • Dual specificity YAK1 related kinase Antibody
  • Dual specificity YAK1-related kinase Antibody
  • DYR1A_HUMAN Antibody
  • DYRK Antibody
  • DYRK 1 Antibody
  • DYRK 1A Antibody
  • DYRK1 Antibody
  • DYRK1A Antibody
  • DYRKA Antibody
  • hMNB Antibody
  • HP 86 Antibody
  • HP86 Antibody
  • Minibrain (Drosophila) homolog Antibody
  • Minibrain homolog Antibody
  • Minibrain, Drosophila, homolog of Antibody
  • MNB Antibody
  • MNB protein kinase Antibody
  • Mnb protein kinase homolog hp86 Antibody
  • MNB protein kinase, Serine/threonine-specific Antibody
  • MNB/DYRK protein kinase Antibody
  • MNBH Antibody
  • MRD7 Antibody
  • OTTHUMP00000109090 Antibody
  • OTTHUMP00000109091 Antibody
  • OTTHUMP00000109094 Antibody
  • OTTHUMP00000174799 Antibody
  • Protein kinase minibrain homolog Antibody
  • Serine/threonine kinase MNB Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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