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Anti-DVL2 Antibody

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产品名称: Anti-DVL2 Antibody
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简单介绍

Anti-DVL2 Antibody


Anti-DVL2 Antibody  的详细介绍
Name: Anti-DVL2 Antibody
See all DVL2 primary antibodies
Description: Rabbit polyclonal antibody to DVL2
Specificity: The antibody detects endogenous levels of total DVL2 protein.
Applications: IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human dishevelled segment polarity protein 2
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Sequence Similarities: Belongs to the DSH family.
Post-Translational Modification: Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).
Cellular Location: Cell membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle. Nucleus.

Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).
Database Links:
  • Entrez Gene: 1856?Human
  • Entrez Gene: 13543?Mouse
  • Omim: 602151?Human
  • SwissProt: O14641?Human
  • SwissProt: Q60838?Mouse
  • Unigene: 118640?Human
  • Unigene: 5114?Mouse
    		•
    Synonyms:
  • Dishevelled 2 Antibody
  • Dishevelled 2 (homologous to Drosophila dsh) Antibody
  • Dishevelled dsh homolog 2 Antibody
  • dishevelled segment polarity protein 2 Antibody
  • Dishevelled-2 Antibody
  • Dishevelled2 Antibody
  • DSH homolog 2 Antibody
  • DVL 2 Antibody
  • Dvl2 Antibody
  • DVL2_HUMAN Antibody
  • Segment polarity protein dishevelled homolog DVL 2 Antibody
  • Segment polarity protein dishevelled homolog DVL-2 Antibody
  • Segment polarity protein dishevelled homolog DVL2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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