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Anti-DUT Antibody

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产品名称: Anti-DUT Antibody
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简单介绍

Anti-DUT Antibody


Anti-DUT Antibody  的详细介绍
Name: Anti-DUT Antibody
See all DUT primary antibodies
Description: Rabbit polyclonal antibody to DUT
Specificity: The antibody detects endogenous level of total DUT antibody.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide of human DUT.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Tissue Specificity: Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).
Sequence Similarities: Belongs to the dUTPase family.
Post-Translational Modification: Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 1854?Human
  • Entrez Gene: 110074?Mouse
  • Entrez Gene: 497778?Rat
  • Omim: 601266?Human
  • SwissProt: P33316?Human
  • SwissProt: P70583?Rat
  • Unigene: 527980?Human
    		•
    Synonyms:
  • Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform Antibody
  • Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Antibody
  • Deoxyuridine triphosphatase Antibody
  • DUT Antibody
  • dUTP nucleotidohydrolase Antibody
  • dUTP pyrophosphatase Antibody
  • dUTPase Antibody
  • DUT_HUMAN Antibody
  • FLJ20622 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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