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Anti-DR5 Antibody

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产品名称: Anti-DR5 Antibody
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简单介绍

Anti-DR5 Antibody


Anti-DR5 Antibody  的详细介绍
Name: Anti-DR5 Antibody
See all DR5 primary antibodies
Description: Mouse monoclonal antibody to DR5
Specificity: This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
Applications: WB, ICC
Dilutions: Western blotting: 1:500-1:2000
Reactivity: Human, Mouse
Immunogen: Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Conjugate: Unconjugated
Purification: Affinity purified
Formulation: Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg / mlBSA and 50% glycerol.
Storage: store at -20˚C
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Tissue Specificity: Widely expressed in ***** and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Involvement in Disease: Squamous cell carcinoma of the head and neck: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 8795 Human
  • Entrez Gene: 21933 Mouse
  • Omim: 603612 Human
  • SwissProt: O14763 Human
  • SwissProt: Q9QZM4 Mouse
  • Unigene: 521456 Human
  • Unigene: 661668 Human
  • Unigene: 193430 Mouse
    		•
    Synonyms:
  • Fas like protein Antibody
  • Apoptosis inducing protein TRICK2A/2B Antibody
  • Apoptosis inducing receptor TRAIL R2 Antibody
  • CD262 Antibody
  • CD262 antigen Antibody
  • Cytotoxic TRAIL receptor 2 Antibody
  • Death domain containing receptor for TRAIL/Apo 2L Antibody
  • Death receptor 5 Antibody
  • DR5 Antibody
  • KILLER Antibody
  • KILLER/DR5 Antibody
  • OTTHUMP00000123492 Antibody
  • OTTHUMP00000123493 Antibody
  • p53 regulated DNA damage inducible cell death receptor(killer) Antibody
  • TNF related apoptosis inducing ligand receptor 2 Antibody
  • TNF-related apoptosis-inducing ligand receptor 2 Antibody
  • TNFRSF10B Antibody
  • TR10B_HUMAN Antibody
  • TRAIL R2 Antibody
  • TRAIL receptor 2 Antibody
  • TRAIL-R2 Antibody
  • TRAILR2 Antibody
  • TRICK2 Antibody
  • TRICK2A Antibody
  • TRICK2B Antibody
  • TRICKB Antibody
  • Tumor necrosis factor receptor like protein ZTNFR9 Antibody
  • Tumor necrosis factor receptor superfamily member 10B Antibody
  • Tumor necrosis factor receptor superfamily, member 10b Antibody
  • ZTNFR9 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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