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Anti-DR4 (D430) Antibody

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产品名称: Anti-DR4 (D430) Antibody
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Anti-DR4 (D430) Antibody


Anti-DR4 (D430) Antibody  的详细介绍
Name: Anti-DR4 (D430) Antibody
See all DR4 primary antibodies
Description: Rabbit polyclonal antibody to DR4 (D430)
Specificity: DR4 (D430) pAb detects endogenous levels of DR4 protein.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 401-450 of Human DR4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 50 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Tissue Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 8797 Human
  • Omim: 603611 Human
  • SwissProt: O00220 Human
  • Unigene: 213467 Human
  • Unigene: 591834 Human
    		•
    Synonyms:
  • Apo2 Antibody
  • CD261 Antibody
  • Cytotoxic TRAIL receptor Antibody
  • Death receptor 4 Antibody
  • DR4 Antibody
  • NF related apoptosis-inducing ligand receptor 1 Antibody
  • TNF receptor superfamily member 10a Antibody
  • TNF-related apoptosis-inducing ligand receptor 1 Antibody
  • TNFRSF10A Antibody
  • TR10A_HUMAN Antibody
  • TRAIL receptor 1 Antibody
  • TRAIL-R1 Antibody
  • TRAILR 1 Antibody
  • TRAILR1 Antibody
  • Tumor necrosis factor receptor superfamily member 10A Antibody
  • Tumor necrosis factor receptor superfamily member 10a variant 2 Antibody
  • Tumor necrosis factor receptor superfamily, member 10a Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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