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Anti-DPYD Antibody

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产品名称: Anti-DPYD Antibody
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简单介绍

Anti-DPYD Antibody


Anti-DPYD Antibody  的详细介绍
Name: Anti-DPYD Antibody
See all DPYD primary antibodies
Description: Rabbit polyclonal antibody to DPYD
Specificity: DPYD pAb detects endogenous levels of DPYD protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human DPYD.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 110 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Tissue Specificity: Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
Involvement in Disease: Dihydropyrimidine dehydrogenase deficiency: A metabolic disorder with large phenotypic variability, ranging from no symptoms to a convulsive disorder with motor and mental retardation. It is characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil.
Sequence Similarities: Belongs to the dihydropyrimidine dehydrogenase family.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 1806?Human
  • Entrez Gene: 99586?Mouse
  • Entrez Gene: 81656?Rat
  • GenBank: AAH08379?Human
  • Omim: 274270?Human
  • Omim: 612779?Human
  • SwissProt: Q12882?Human
  • SwissProt: Q8CHR6?Mouse
  • SwissProt: O89000?Rat
  • Unigene: 335034?Human
  • Unigene: 27907?Mouse
  • Unigene: 158382?Rat
    		•
    Synonyms:
  • DHP Antibody
  • DHPDHase Antibody
  • Dihydropyrimidine dehydrogenase Antibody
  • Dihydropyrimidine dehydrogenase [NADP(+)] Antibody
  • Dihydropyrimidine dehydrogenase [NADP+] Antibody
  • Dihydrothymine dehydrogenase Antibody
  • Dihydrouracil dehydrogenase Antibody
  • DPD Antibody
  • DPYD Antibody
  • DPYD_HUMAN Antibody
  • MGC132008 Antibody
  • MGC70799 Antibody
  • OTTHUMP00000058954 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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