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Anti-DPM3 Antibody

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产品名称: Anti-DPM3 Antibody
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简单介绍

Anti-DPM3 Antibody


Anti-DPM3 Antibody  的详细介绍
Name: Anti-DPM3 Antibody
See all DPM3 primary antibodies
Description: Goat polyclonal antibody to DPM3.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human DPM3 (internal region).
Sequence: HDCEDAARELQSQ
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.
Involvement in Disease: Congenital disorder of glycosylation 1O: A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1O patients have increased serum creatine kinase, dystrophic changes on muscle biopsy, and reduced O-mannosylation of alpha-dystroglycan.
Sequence Similarities: Belongs to the DPM3 family.
Cellular Location: Endoplasmic reticulum membrane.
Database Links:
  • Entrez Gene: 54344 Human
  • Omim: 605951 Human
  • SwissProt: Q9P2X0 Human
  • Unigene: 110477 Human
    		•
    Synonyms:
  • CDG1O Antibody
  • Dolichol Phosphate Mannose Synthase subunit 3 Antibody
  • Dolichol phosphate mannosyltransferase subunit 3 Antibody
  • Dolichyl Phosphate beta D Mannosyltransferase subunit 3 Antibody
  • Dolichyl phosphate mannosyltransferase polypeptide 3 Antibody
  • DPM synthase complex subunit 3 Antibody
  • DPM3 Antibody
  • Mannose P Dolichol Synthase subunit 3 Antibody
  • MPD synthase subunit 3 Antibody
  • Prostin 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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