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Anti-DOK2 Antibody

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产品名称: Anti-DOK2 Antibody
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简单介绍

Anti-DOK2 Antibody


Anti-DOK2 Antibody  的详细介绍
Name: Anti-DOK2 Antibody
See all DOK2 primary antibodies
Description: Rabbit polyclonal antibody to DOK2
Specificity: The antibody detects endogenous levels of total DOK2 protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide of human DOK2
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification
Concentration: 0.4mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
Tissue Specificity: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Sequence Similarities: Belongs to the DOK family. Type A subfamily.
Post-Translational Modification: On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
Database Links:
  • Entrez Gene: 9046?Human
  • Omim: 604997?Human
  • SwissProt: O60496?Human
  • Unigene: 71215?Human
    		•
    Synonyms:
  • Docking protein 2 Antibody
  • Docking protein 2 56kDa Antibody
  • DOK 2 Antibody
  • DOK R Antibody
  • DOK2 Antibody
  • DOK2_HUMAN Antibody
  • Downstream of tyrosine kinase 2 Antibody
  • OTTHUMP00000161710 Antibody
  • OTTHUMP00000224923 Antibody
  • p56(dok 2) Antibody
  • p56(dok-2) Antibody
  • p56DOK Antibody
  • p56dok 2 Antibody
  • p56dok2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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