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Anti-DOK1 Antibody

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产品名称: Anti-DOK1 Antibody
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简单介绍

Anti-DOK1 Antibody


Anti-DOK1 Antibody  的详细介绍
Name: Anti-DOK1 Antibody
See all DOK1 primary antibodies
Description: Rabbit polyclonal antibody to DOK1
Applications: E, WB, ICC
Reactivity: Human
Immunogen: Raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same on ITGB3.
Tissue Specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Sequence Similarities: Belongs to the DOK family. Type A subfamily.
Post-Translational Modification: Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 1796 Human
  • Omim: 602919 Human
  • SwissProt: Q99704 Human
  • Unigene: 103854 Human
    		•
    Synonyms:
  • Docking protein 1 Antibody
  • Docking protein 1 62kD Antibody
  • DOK 1 Antibody
  • DOK1 Antibody
  • DOK1_HUMAN Antibody
  • Downstream of tyrosine kinase 1 Antibody
  • p62(dok) Antibody
  • P62DOK Antibody
  • pp62 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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