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Anti-DNAJA3 Antibody

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产品名称: Anti-DNAJA3 Antibody
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Anti-DNAJA3 Antibody


Anti-DNAJA3 Antibody  的详细介绍
Name: Anti-DNAJA3 Antibody
See all DNAJA3 primary antibodies
Description: Rabbit polyclonal antibody to DNAJA3.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DNAJA3.
Protein Length: 480
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Tissue Specificity: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Post-Translational Modification: Tyrosine phosphorylated.
Cellular Location: Mitochondrion matrix. Cytoplasm > Cytosol. Cell junction > Synapse > Postsynaptic cell membrane.

Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.
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