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Anti-DLG1 Antibody

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产品名称: Anti-DLG1 Antibody
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简单介绍

Anti-DLG1 Antibody


Anti-DLG1 Antibody  的详细介绍
Name: Anti-DLG1 Antibody
See all SAP97 primary antibodies
Description: Goat polyclonal antibody to DLG1.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human DLG1 (internal region).
Sequence: C-NSKTRDKGEIPDD
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.
Tissue Specificity: Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles.
Sequence Similarities: Belongs to the MAGUK family.
Post-Translational Modification: Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity).
Cellular Location: Membrane. Basolateral cell membrane. Endoplasmic reticulum membrane. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density. Cell junction > Synapse. Cell membrane > Sarcolemma.

Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity).
Database Links:
  • Entrez Gene: 1739 Human
  • Omim: 601014 Human
  • SwissProt: Q12959 Human
  • Unigene: 292549 Human
    		•
    Synonyms:
  • Discs large homolog 1 Antibody
  • discs large, Drosophila, homolog of, 1 Antibody
  • discs, large homolog 1 (Drosophila) Antibody
  • Disks large homolog 1 Antibody
  • dJ1061C18.1.1 Antibody
  • DKFZp761P0818 Antibody
  • DKFZp781B0426 Antibody
  • DLG 1 Antibody
  • DLG1 Antibody
  • DLG1_HUMAN Antibody
  • DLGH 1 Antibody
  • DLGH1 Antibody
  • hDlg Antibody
  • Presynaptic protein SAP97 Antibody
  • SAP 97 Antibody
  • SAP-97 Antibody
  • SAP97 Antibody
  • Synapse associated protein 97 Antibody
  • Synapse-associated protein 97 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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