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Anti-DLC1 Antibody

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产品名称: Anti-DLC1 Antibody
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简单介绍

Anti-DLC1 Antibody


Anti-DLC1 Antibody  的详细介绍
Name: Anti-DLC1 Antibody
See all DLC1 primary antibodies
Description: Rabbit polyclonal antibody to DLC1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DLC1.
Protein Length: 1528(463)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
Tissue Specificity: Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.
Cellular Location: Cytoplasm. Cell junction > Focal adhesion. Membrane.

Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Database Links:
  • Entrez Gene: 10395?Human
  • Entrez Gene: 50768?Mouse
  • Entrez Gene: 58834?Rat
  • Omim: 604258?Human
  • SwissProt: Q96QB1?Human
  • SwissProt: Q9R0Z9?Mouse
  • SwissProt: Q63744?Rat
  • Unigene: 134296?Human
  • Unigene: 210875?Mouse
  • Unigene: 224563?Rat
    		•
    Synonyms:
  • ARHGAP 7 Antibody
  • ARHGAP7 Antibody
  • Deleted in liver cancer 1 Antibody
  • Deleted in liver cancer 1 protein Antibody
  • DLC 1 Antibody
  • Dlc-1 Antibody
  • DLC1 Antibody
  • DLC1 Rho GTPase activating protein Antibody
  • FLJ21120 Antibody
  • HP Antibody
  • HP protein Antibody
  • KIAA1723 Antibody
  • p122 RhoGAP Antibody
  • RHG07_HUMAN Antibody
  • Rho GTPase activating protein 7 Antibody
  • Rho GTPase-activating protein 7 Antibody
  • Rho type GTPase activating protein 7 Antibody
  • Rho-type GTPase-activating protein 7 Antibody
  • StAR related lipid transfer (START) domain containing 12 Antibody
  • StAR related lipid transfer protein 12 Antibody
  • StAR-related lipid transfer protein 12 Antibody
  • STARD 12 Antibody
  • StARD12 Antibody
  • START domain containing protein 12 Antibody
  • START domain-containing protein 12 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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