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Anti-DLAT Antibody

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产品名称: Anti-DLAT Antibody
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Anti-DLAT Antibody


Anti-DLAT Antibody  的详细介绍
Name: Anti-DLAT Antibody
See all DLAT primary antibodies
Description: Rabbit polyclonal antibody to DLAT.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DLAT.
Protein Length: 647
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Involvement in Disease: Pyruvate dehydrogenase E2 deficiency: Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. In this form of PDH deficiency episodic dystonia is the major neurological manifestation, with other more common features of pyruvate dehydrogenase deficiency, such as hypotonia and ataxia, being less prominent.
Sequence Similarities: Belongs to the 2-oxoacid dehydrogenase family.
Post-Translational Modification: Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity.
Cellular Location: Mitochondrion matrix.
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