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Anti-DKK4 Antibody

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产品名称: Anti-DKK4 Antibody
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简单介绍

Anti-DKK4 Antibody


Anti-DKK4 Antibody  的详细介绍
Name: Anti-DKK4 Antibody
See all DKK4 primary antibodies
Description: Rabbit polyclonal antibody to DKK4
Specificity: The antibody detects endogenous levels of total DKK4 protein.
Applications: IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from internal residues of human dickkopf WNT signaling pathway inhibitor 4
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Tissue Specificity: Expressed in cerebellum, T-cells, esophagus and lung.
Sequence Similarities: Belongs to the dickkopf family.
Post-Translational Modification: Appears to be not glycosylated.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 27121?Human
  • GenBank: NP_055235.1?Human
  • Omim: 605417?Human
  • SwissProt: Q9UBT3?Human
  • Unigene: 159311?Human
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    Synonyms:
  • Dickkopf 4 Antibody
  • Dickkopf gene 4 Antibody
  • Dickkopf homolog 4 Antibody
  • Dickkopf homolog 4 (Xenopus laevis) Antibody
  • Dickkopf related protein 4 Antibody
  • Dickkopf-4 Antibody
  • Dickkopf-related protein 4 short form Antibody
  • Dickkopf4 Antibody
  • DKK 4 Antibody
  • Dkk-4 Antibody
  • DKK4 Antibody
  • DKK4_HUMAN Antibody
  • hDkk 4 Antibody
  • hDkk-4 Antibody
  • hDkk4 Antibody
  • MGC129562 Antibody
  • MGC129563 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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