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Anti-DKK3 Antibody

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产品名称: Anti-DKK3 Antibody
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简单介绍

Anti-DKK3 Antibody


Anti-DKK3 Antibody  的详细介绍
Name: Anti-DKK3 Antibody
See all DKK3 primary antibodies
Description: Rabbit polyclonal antibody to DKK3
Specificity: DKK3 pAb detects endogenous levels of DKK3 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human DKK3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~38 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Tissue Specificity: Highest expression in heart, brain, and spinal cord.
Sequence Similarities: Belongs to the dickkopf family.
Post-Translational Modification: N- and O-glycosylated.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 27122?Human
  • Entrez Gene: 50781?Mouse
  • Entrez Gene: 171548?Rat
  • Omim: 605416?Human
  • SwissProt: Q9UBP4?Human
  • SwissProt: Q9QUN9?Mouse
  • Unigene: 292156?Human
  • Unigene: 55143?Mouse
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    Synonyms:
  • Dickkopf 3 Antibody
  • Dickkopf 3 homolog Antibody
  • Dickkopf 3 homolog (Xenopus laevis) Antibody
  • Dickkopf homolog 3 Antibody
  • Dickkopf related protein 3 Antibody
  • Dickkopf related protein 3 Precursor Antibody
  • Dickkopf WNT signaling pathway inhibitor 3 Antibody
  • Dickkopf, Xenopus, homolog of, 3 Antibody
  • Dickkopf-3 Antibody
  • Dickkopf-related protein 3 Antibody
  • Dickkopf3 Antibody
  • DKK 3 Antibody
  • Dkk-3 Antibody
  • Dkk3 Antibody
  • DKK3_HUMAN Antibody
  • hDkk 3 Antibody
  • hDkk-3 Antibody
  • hDkk3 Antibody
  • Regulated in glioma Antibody
  • REIC Antibody
  • RIG Antibody
  • RIG-like 5-6 Antibody
  • RIG-like 7-1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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