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Anti-DKK1 Antibody

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产品名称: Anti-DKK1 Antibody
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简单介绍

Anti-DKK1 Antibody


Anti-DKK1 Antibody  的详细介绍
Name: Anti-DKK1 Antibody
See all DKK1 primary antibodies
Description: Rabbit polyclonal antibody to DKK1
Specificity: DKK1 pAb detects endogenous levels of DKK1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human DKK1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 29 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Tissue Specificity: Placenta.
Sequence Similarities: Belongs to the dickkopf family.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 22943?Human
  • Entrez Gene: 13380?Mouse
  • Entrez Gene: 293897?Rat
  • Omim: 605189?Human
  • SwissProt: O94907?Human
  • SwissProt: O54908?Mouse
  • Unigene: 40499?Human
  • Unigene: 214717?Mouse
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    Synonyms:
  • Dickkopf 1 Antibody
  • Dickkopf 1 homolog Antibody
  • Dickkopf 1 like Antibody
  • Dickkopf homolog 1 Antibody
  • Dickkopf like protein 1 Antibody
  • Dickkopf related protein 1 Antibody
  • Dickkopf WNT signaling pathway inhibitor 1 Antibody
  • Dickkopf-1 Antibody
  • Dickkopf-related protein 1 Antibody
  • DKK 1 Antibody
  • Dkk-1 Antibody
  • DKK1 Antibody
  • DKK1_HUMAN Antibody
  • hDkk 1 Antibody
  • hDkk-1 Antibody
  • hDkk1 Antibody
  • mDkk1 Antibody
  • SK Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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