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Anti-DISC1 Antibody

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产品名称: Anti-DISC1 Antibody
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Anti-DISC1 Antibody


Anti-DISC1 Antibody  的详细介绍
Name: Anti-DISC1 Antibody
See all DISC1 primary antibodies
Description: Rabbit polyclonal antibody to DISC1
Applications: E, WB, ICC
Reactivity: Human, Mouse
Immunogen: Raised against a 18 amino acid peptide from near the center of human DISC1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Involved in the regulation of multiple aspects of embryonic and ***** neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the ***** dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during ***** neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
Tissue Specificity: Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb.
Cellular Location: Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density.

Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria.
Database Links:
  • Entrez Gene: 27185 Human
  • Entrez Gene: 244667 Mouse
  • Omim: 605210 Human
  • SwissProt: Q9NRI5 Human
  • SwissProt: Q811T9 Mouse
  • Unigene: 13318 Human
  • Unigene: 233504 Mouse
    		•
    Synonyms:
  • C1orf136 Antibody
  • DISC1 Antibody
  • DISC1_HUMAN Antibody
  • Disrupted in schizophrenia 1 Antibody
  • Disrupted in schizophrenia 1 protein Antibody
  • KIAA0457 Antibody
  • RP4-730B13.1 Antibody
  • SCZD9 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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