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Anti-DIL-2 Antibody

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产品名称: Anti-DIL-2 Antibody
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Anti-DIL-2 Antibody


Anti-DIL-2 Antibody  的详细介绍
Name: Anti-DIL-2 Antibody
See all DIL-2 primary antibodies
Description: Rabbit polyclonal antibody to DIL-2
Specificity: The antibody detects endogenous levels of total DIL-2 protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from internal of human DIL-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Tissue Specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues.
Sequence Similarities: Belongs to the TPX2 family.
Cellular Location: Nucleus. Cytoplasm > Cytoskeleton > Spindle. Cytoplasm > Cytoskeleton > Spindle pole.

During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Database Links:
  • Entrez Gene: 22974?Human
  • Entrez Gene: 72119?Mouse
  • Omim: 605917?Human
  • SwissProt: Q9ULW0?Human
  • SwissProt: A2APB8?Mouse
  • Unigene: 244580?Human
  • Unigene: 407737?Mouse
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    Synonyms:
  • C20ORF1 Antibody
  • C20orf2 Antibody
  • Chromosome 20 Open Reading Frame 1 Antibody
  • Differentially expressed in cancerous and non-cancerous lung cells 2 Antibody
  • Differentially expressed in cancerous and noncancerous lung cells 2 Antibody
  • Differentially expressed in lung cells Antibody
  • Differentially expressed in lung cells 2 Antibody
  • DIL 2 Antibody
  • DIL-2 Antibody
  • DIL2 Antibody
  • FLS353 Antibody
  • GD:C20orf1 Antibody
  • HCA 519 Antibody
  • HCA519 Antibody
  • HCTP 4 Antibody
  • HCTP4 Antibody
  • Hepatocellular carcinoma associated antigen 519 Antibody
  • Hepatocellular carcinoma-associated antigen 519 Antibody
  • p100 Antibody
  • Preferentially expressed in colorectal cancer Antibody
  • Protein fls353 Antibody
  • REPP 86 Antibody
  • repp86 Antibody
  • Restricted expression proliferation associated protein 100 Antibody
  • Restricted expression proliferation-associated protein 100 Antibody
  • Targeting protein for Xklp2 Antibody
  • TPX 2 Antibody
  • TPX2 Antibody
  • TPX2 microtubule associated homolog Antibody
  • TPX2 microtubule associated protein homolog Antibody
  • TPX2 microtubule nucleation factor Antibody
  • TPX2_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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