产品资料

Anti-DIABLO Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-DIABLO Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-DIABLO Antibody


Anti-DIABLO Antibody  的详细介绍
Name: Anti-DIABLO Antibody
See all DIABLO primary antibodies
Description: Rabbit polyclonal antibody to DIABLO
Specificity: The antibody detects endogenous level of total DIABLO protein.
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from 56-239 amino acids of human diablo, IAP-binding mitochondrial protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Formulation: Supplied at 2.2mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Tissue Specificity: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
Involvement in Disease: Deafness, autosomal dominant, 64: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Post-Translational Modification: Ubiquitinated by BIRC7/livin.
Cellular Location: Mitochondrion.

Released into the cytosol when cells undergo apoptosis.
Database Links:
  • Entrez Gene: 56616?Human
  • Omim: 605219?Human
  • SwissProt: Q9NR28?Human
  • Unigene: 169611?Human
    		•
    Synonyms:
  • 0610041G12Rik Antibody
  • DBLOH_HUMAN Antibody
  • DBOH Antibody
  • DFNA64 Antibody
  • diablo Antibody
  • Diablo homolog Antibody
  • Diablo homolog (Drosophila) Antibody
  • Diablo homolog mitochondrial Antibody
  • Diablo IAP binding mitochondrial protein Antibody
  • Diablo like protein Antibody
  • DIABLO S Antibody
  • Direct IAP binding protein with low pI Antibody
  • Direct IAP-binding protein with low pI Antibody
  • FLJ10537 Antibody
  • FLJ25049 Antibody
  • mitochondrial Antibody
  • Mitochondrial Smac protein Antibody
  • Second mitochondria derived activator of caspase Antibody
  • Second mitochondria-derived activator of caspase Antibody
  • Smac Antibody
  • Smac / Diablo Antibody
  • SMAC 3 Antibody
  • Smac protein Antibody
  • SMAC3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号