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Anti-DGKH Antibody

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产品名称: Anti-DGKH Antibody
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简单介绍

Anti-DGKH Antibody


Anti-DGKH Antibody  的详细介绍
Name: Anti-DGKH Antibody
See all DGKH primary antibodies
Description: Rabbit polyclonal antibody to DGKH
Specificity: The antibody detects endogenous levels of total DGKH protein
Applications: IHC, IF
Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human DGKH.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Tissue Specificity: Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon.
Sequence Similarities: Belongs to the eukaryotic diacylglycerol kinase family.
Post-Translational Modification: Phosphorylated; does not inhibit catalytic activity.
Cellular Location: Cytoplasm. Cell membrane.

Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).
Database Links:
  • Entrez Gene: 160851?Human
  • Omim: 604071?Human
  • SwissProt: Q86XP1?Human
    		•
    Synonyms:
  • DAG kinase eta Antibody
  • DGK eta Antibody
  • DGKH Antibody
  • Diacylglycerol kinase eta Antibody
  • Diglyceride kinase eta Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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