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Anti-DGK-ε (S194) Antibody

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产品名称: Anti-DGK-ε (S194) Antibody
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Anti-DGK-ε (S194) Antibody


Anti-DGK-ε (S194) Antibody  的详细介绍
Name: Anti-DGK-ε (S194) Antibody
See all DGK-ε primary antibodies
Description: Rabbit polyclonal antibody to DGK-ε (S194)
Specificity: DGK-ε (S194) pAb detects endogenous levels of DGK-ε protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human DGK-ε.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 64 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
Tissue Specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).
Involvement in Disease: Nephrotic syndrome 7: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. NPHS7 is an autosomal recessive form characterized by onset of proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis.

Hemolytic uremic syndrome atypical 7: An atypical form of hemolytic uremic syndrome characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system.
Sequence Similarities: Belongs to the eukaryotic diacylglycerol kinase family.
Cellular Location: Membrane. Membrane. Cytoplasm.
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