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Anti-DEDD Antibody

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产品名称: Anti-DEDD Antibody
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简单介绍

Anti-DEDD Antibody


Anti-DEDD Antibody  的详细介绍
Name: Anti-DEDD Antibody
See all DEDD primary antibodies
Description: Rabbit polyclonal antibody to DEDD
Applications: WB, IF
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 129 and 193 of human DEDD
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).
Tissue Specificity: Widely expressed with highest levels in testis.
Post-Translational Modification: Exists predominantly in a mono- or diubiquitinated form.
Cellular Location: Cytoplasm. Nucleus > Nucleolus.

Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.
Database Links:
  • Entrez Gene: 9191 Human
  • Omim: 606841 Human
  • SwissProt: O75618 Human
  • Unigene: 146406 Human
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    Synonyms:
  • CASP8IP1 Antibody
  • Death effector domain containing Antibody
  • Death effector domain containing protein Antibody
  • Death effector domain containing testicular molecule Antibody
  • Death effector domain-containing protein Antibody
  • Death effector domain-containing testicular molecule Antibody
  • DEDD Antibody
  • DEDD 1 Antibody
  • DEDD1 Antibody
  • DEDD_HUMAN Antibody
  • DEDPro 1 Antibody
  • DEDPro1 Antibody
  • DEFT Antibody
  • FLDED 1 Antibody
  • FLDED-1 Antibody
  • FLDED1 Antibody
  • KE 05 Antibody
  • KE05 Antibody
  • OTTHUMP00000031822 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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