产品资料

Anti-DEDAF Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-DEDAF Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-DEDAF Antibody


Anti-DEDAF Antibody  的详细介绍
Name: Anti-DEDAF Antibody
See all DEDAF primary antibodies
Description: Rabbit polyclonal antibody to DEDAF
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a synthetic peptide corresponding to amino acids 215 to 228 of human DEDAF. The sequence is identical to that of mouse origin.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA (PubMed:19170609).
Tissue Specificity: Expressed in embryonic stem cells.
Post-Translational Modification: Monoubiquitinated.
Cellular Location: Nucleus. Cytoplasm. Nucleus > Nucleoplasm.

Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.
Database Links:
  • Entrez Gene: 23429?Human
  • Entrez Gene: 56353?Mouse
  • Entrez Gene: 312603?Rat
  • Omim: 607535?Human
  • SwissProt: Q8N488?Human
  • SwissProt: Q8CCI5?Mouse
  • Unigene: 7910?Human
  • Unigene: 321633?Mouse
  • Unigene: 33148?Rat
    		•
    Synonyms:
  • 2410018J24Rik Antibody
  • AAP 1 Antibody
  • AAP1 Antibody
  • APAP 1 Antibody
  • APAP-1 Antibody
  • APAP1 Antibody
  • Apoptin associating protein 1 Antibody
  • Apoptin-associating protein 1 Antibody
  • cb337 Antibody
  • Death effector domain associated factor Antibody
  • Death effector domain-associated factor Antibody
  • Death effector domain-associated factor B Antibody
  • DED associated factor Antibody
  • DED-associated factor Antibody
  • DED-associated factor B Antibody
  • DEDAF Antibody
  • MGC62213 Antibody
  • RING1 and YY1 binding protein Antibody
  • RING1 and YY1 binding protein a Antibody
  • RING1 and YY1-binding protein Antibody
  • RING1 and YY1-binding protein B Antibody
  • Ring1 interactor RYBP Antibody
  • RYBP Antibody
  • rybpa Antibody
  • RYBP_HUMAN Antibody
  • wu:fi34f03 Antibody
  • YEAF 1 Antibody
  • YEAF1 Antibody
  • YY1 and E4TF1 associated factor 1 Antibody
  • YY1 and E4TF1-associated factor 1 Antibody
  • YY1- and E4TF1/GABP-associated factor 1 Antibody
  • zgc:153842 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号