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Anti-DDX20 Antibody

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产品名称: Anti-DDX20 Antibody
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简单介绍

Anti-DDX20 Antibody


Anti-DDX20 Antibody  的详细介绍
Name: Anti-DDX20 Antibody
See all DDX20 primary antibodies
Description: Rabbit polyclonal antibody to DDX20.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DDX20.
Protein Length: 824
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Tissue Specificity: Ubiquitous.
Sequence Similarities: Belongs to the DEAD box helicase family. DDX20 subfamily.
Cellular Location: Cytoplasm. Nucleus > Gem.

Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Database Links:
  • Entrez Gene: 11218?Human
  • Entrez Gene: 53975?Mouse
  • Entrez Gene: 84473?Rat
  • Omim: 606168?Human
  • SwissProt: Q9UHI6?Human
  • SwissProt: Q9JJY4?Mouse
  • Unigene: 591405?Human
  • Unigene: 272826?Mouse
  • Unigene: 137424?Rat
    		•
    Synonyms:
  • Component of gems 3 Antibody
  • DDX 20 Antibody
  • ddx20 Antibody
  • DDX20_HUMAN Antibody
  • DEAD (Asp Glu Ala Asp) box polypeptide 20 Antibody
  • DEAD box protein 20 Antibody
  • DEAD box protein DP 103 Antibody
  • DEAD box protein DP103 Antibody
  • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 Antibody
  • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD Antibody
  • DEAD/H BOX 20 Antibody
  • DKFZP434H052 Antibody
  • DP 103 Antibody
  • DP103 Antibody
  • Gemin 3 Antibody
  • Gemin-3 Antibody
  • Gemin3 Antibody
  • Probable ATP dependent RNA helicase DDX20 Antibody
  • Probable ATP-dependent RNA helicase ddx20 Antibody
  • SMN interacting protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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