产品资料

Anti-DDX11 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-DDX11 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-DDX11 Antibody


Anti-DDX11 Antibody  的详细介绍
Name: Anti-DDX11 Antibody
See all DDX11 primary antibodies
Description: Rabbit polyclonal antibody to DDX11
Specificity: The antibody detects endogenous levels of total DDX11 protein.
Applications: IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from internal residues of human DEAD / H (Asp-Glu-Ala-Asp / His) box helicase 11
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414).
Tissue Specificity: Expressed in melanoma cells. Not detected in epidermal melanocytes of normal skin (at protein level) (PubMed:23116066). Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine and pancreas (PubMed:9013641). Very low expression seen in brain (PubMed:9013641). Expressed in dividing cells and/or cells undergoing high levels of recombination (PubMed:9013641). No expression detected in cells signaled to terminally differentiate (PubMed:9013641). Expressed weakly in keratinocytes (PubMed:8798685).
Involvement in Disease: Warsaw breakage syndrome: A syndrome characterized by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation. Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect, toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, and sister chromatid cohesion defects, a feature of Roberts syndrome, coexist.
Sequence Similarities: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
Cellular Location: Nucleus. Nucleus > Nucleolus. Cytoplasm > Cytoskeleton > Spindle pole. Midbody. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase) (PubMed:17105772). In interphase, colocalizes with nucleolin in the nucleolus (PubMed:26089203).
Database Links:
  • Entrez Gene: 1663?Human
  • Omim: 601150?Human
  • SwissProt: Q96FC9?Human
  • Unigene: 443960?Human
    		•
    Synonyms:
  • CHL1 Antibody
  • CHL1 related helicase gene 1 Antibody
  • CHL1-like helicase homolog Antibody
  • CHL1-related protein 1 Antibody
  • CHLR1 Antibody
  • DDX11 Antibody
  • DDX11_HUMAN Antibody
  • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 Antibody
  • DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 Antibody
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) Antibody
  • DEAD/H box Antibody
  • DEAD/H box protein 11 Antibody
  • hCHLR1 Antibody
  • Keratinocyte growth factor regulated gene 2 protein Antibody
  • Keratinocyte growth factor-regulated gene 2 protein Antibody
  • KRG 2 Antibody
  • KRG-2 Antibody
  • KRG2 Antibody
  • MGC133249 Antibody
  • MGC9335 Antibody
  • OTTHUMP00000238778 Antibody
  • OTTHUMP00000238780 Antibody
  • OTTHUMP00000238784 Antibody
  • OTTHUMP00000238785 Antibody
  • Probable ATP dependent RNA helicase DDX11 Antibody
  • Probable ATP-dependent RNA helicase DDX11 Antibody
  • WABS Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号