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Anti-DDK1 Antibody

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产品名称: Anti-DDK1 Antibody
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Anti-DDK1 Antibody


Anti-DDK1 Antibody  的详细介绍
Name: Anti-DDK1 Antibody
See all DDK1 primary antibodies
Description: Rabbit polyclonal antibody to DDK1
Specificity: The antibody detects endogenous levels of total DDK1 protein.
Applications: IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human dickkopf WNT signaling pathway inhibitor 1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.2mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Tissue Specificity: Placenta.
Sequence Similarities: Belongs to the dickkopf family.
Cellular Location: Secreted.
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