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Anti-DDB1 Antibody

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产品名称: Anti-DDB1 Antibody
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Anti-DDB1 Antibody


Anti-DDB1 Antibody  的详细介绍
Name: Anti-DDB1 Antibody
See all DDB1 primary antibodies
Description: Rabbit polyclonal antibody to DDB1
Specificity: The antibody detects endogenous level of total DDB1 protein.
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to a region derived from 1125-1140 amino acids of Human DNA damage-binding protein 1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Formulation: Supplied at 0.9mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2 (By similarity).
Sequence Similarities: Belongs to the DDB1 family.
Post-Translational Modification: Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis (By similarity).
Cellular Location: Cytoplasm. Nucleus.

Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (By similarity).
Database Links:
  • Entrez Gene: 100290337?Human
  • Entrez Gene: 1642?Human
  • Entrez Gene: 13194?Mouse
  • Entrez Gene: 64470?Rat
  • Omim: 600045?Human
  • SwissProt: Q16531?Human
  • SwissProt: Q3U1J4?Mouse
  • SwissProt: Q9ESW0?Rat
  • Unigene: 290758?Human
  • Unigene: 289915?Mouse
  • Unigene: 466856?Mouse
  • Unigene: 8402?Rat
    		•
    Synonyms:
  • Damage specific DNA binding protein 1 Antibody
  • Damage-specific DNA-binding protein 1 Antibody
  • DDB 1 Antibody
  • DDB p127 subunit Antibody
  • DDB1 Antibody
  • DDB1_HUMAN Antibody
  • DDBa Antibody
  • DNA damage binding protein 1 Antibody
  • DNA damage-binding protein 1 Antibody
  • DNA damage-binding protein a Antibody
  • HBV X-associated protein 1 Antibody
  • UV damaged DNA binding factor Antibody
  • UV damaged DNA binding protein 1 Antibody
  • UV DDB 1 Antibody
  • UV DDB1 Antibody
  • UV-damaged DNA-binding factor Antibody
  • UV-damaged DNA-binding protein 1 Antibody
  • UV-DDB 1 Antibody
  • X associated protein 1 Antibody
  • XAP 1 Antibody
  • XAP-1 Antibody
  • XAP1 Antibody
  • Xeroderma pigmentosum group E complementing protein Antibody
  • Xeroderma pigmentosum group E-complementing protein Antibody
  • XPCe Antibody
  • XPE Antibody
  • XPE BF Antibody
  • XPE binding factor Antibody
  • XPE-BF Antibody
  • XPE-binding factor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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