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Anti-DCTN4 Antibody

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产品名称: Anti-DCTN4 Antibody
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简单介绍

Anti-DCTN4 Antibody


Anti-DCTN4 Antibody  的详细介绍
Name: Anti-DCTN4 Antibody
See all DCTN4 primary antibodies
Description: Rabbit polyclonal antibody to DCTN4
Specificity: The antibody detects endogenous levels of total DCTN4 protein.
Applications: IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human dynactin 4 (p62)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Sequence Similarities: Belongs to the dynactin subunit 4 family.
Cellular Location: Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.
Database Links:
  • Entrez Gene: 51164?Human
  • SwissProt: Q9UJW0?Human
  • Unigene: 675564?Human
    		•
    Synonyms:
  • DCTN 4 Antibody
  • DCTN4 Antibody
  • DCTN4_HUMAN Antibody
  • Dynactin 4 Antibody
  • Dynactin 4 (p62) Antibody
  • Dynactin p62 subunit Antibody
  • Dynactin subunit 4 Antibody
  • Dynactin subunit p62 Antibody
  • Dynactin4 Antibody
  • p62 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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