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Anti-DCP1A Antibody

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产品名称: Anti-DCP1A Antibody
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简单介绍

Anti-DCP1A Antibody


Anti-DCP1A Antibody  的详细介绍
Name: Anti-DCP1A Antibody
See all DCP1A primary antibodies
Description: Rabbit polyclonal antibody to DCP1A
Specificity: The antibody detects endogenous levels of total DCP1A protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human decapping mRNA 1A
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
Tissue Specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Sequence Similarities: Belongs to the DCP1 family.
Cellular Location: Cytoplasm > P-body. Nucleus.

Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).
Database Links:
  • Entrez Gene: 55802?Human
  • Omim: 607010?Human
  • SwissProt: Q9NPI6?Human
  • Unigene: 476353?Human
    		•
    Synonyms:
  • DCP1 decapping enzyme homolog A Antibody
  • Dcp1a Antibody
  • DCP1A_HUMAN Antibody
  • Decapping enzyme hDcp1a Antibody
  • Decapping mRNA 1A Antibody
  • HSA275986 Antibody
  • mRNA decapping enzyme 1A Antibody
  • mRNA-decapping enzyme 1A Antibody
  • Nbla00360 Antibody
  • Putative protein product of Nbla00360 Antibody
  • Smad4 interacting transcriptional co activator Antibody
  • Smad4-interacting transcriptional co-activator Antibody
  • SMAD4IP1 Antibody
  • SMIF Antibody
  • Transcription factor SMIF Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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