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Anti-DARC Antibody

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产品名称: Anti-DARC Antibody
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简单介绍

Anti-DARC Antibody


Anti-DARC Antibody  的详细介绍
Name: Anti-DARC Antibody
See all DARC primary antibodies
Description: Rabbit polyclonal antibody to DARC
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Raised against a 18 amino acid peptide from near the amino terminus of human DARC.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Tissue Specificity: Found in ***** kidney, ***** spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the ***** liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
Cellular Location: Early endosome. Recycling endosome. Membrane.

Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Database Links:
  • Entrez Gene: 2532?Human
  • Omim: 110700?Human
  • SwissProt: Q16570?Human
  • Unigene: 153381?Human
    		•
    Synonyms:
  • CCBP1 Antibody
  • CD234 Antibody
  • DARC Antibody
  • Dfy Antibody
  • Duffy antigen/chemokine receptor Antibody
  • duffy blood group Antibody
  • Duffy blood group antigen Antibody
  • Duffy blood group chemokine receptor Antibody
  • DUFFY_HUMAN Antibody
  • FY Antibody
  • Fy glycoprotein Antibody
  • Glycoprotein D Antibody
  • GPD Antibody
  • GpFy Antibody
  • Plasmodium vivax receptor Antibody
  • WBCQ1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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