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Anti-DAPK2 Antibody

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产品名称: Anti-DAPK2 Antibody
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Anti-DAPK2 Antibody


Anti-DAPK2 Antibody  的详细介绍
Name: Anti-DAPK2 Antibody
See all DAPK2 primary antibodies
Description: Rabbit polyclonal antibody to DAPK2
Specificity: DAPK2 has no cross responses to DAPK1.
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a peptide corresponding to amino acids near the carboxy terminus of human DAPK2. The sequence of. This antigenic peptide is identical to the corresponding amino acids of mouse origin (1,2).
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421).
Tissue Specificity: Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the ***** brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167).
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Post-Translational Modification: Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.
Cellular Location: Cytoplasm. Cytoplasmic vesicle > Autophagosome lumen.
Database Links:
  • Entrez Gene: 23604?Human
  • Entrez Gene: 13143?Mouse
  • Entrez Gene: 300799?Rat
  • Omim: 604727?Human
  • SwissProt: Q9UIK4?Human
  • SwissProt: Q8VDF3?Mouse
  • Unigene: 237886?Human
  • Unigene: 304472?Mouse
  • Unigene: 335252?Mouse
  • Unigene: 98325?Rat
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    Synonyms:
  • DAK2 Antibody
  • DAP Kinase 2 Antibody
  • DAP kinase related protein 1 Antibody
  • DAP kinase related protein 1 beta isoform Antibody
  • DAP-kinase-related protein 1 Antibody
  • DAPK2 Antibody
  • DAPK2_HUMAN Antibody
  • Death associated protein kinase 2 Antibody
  • Death-associated protein kinase 2 Antibody
  • DRP 1 Antibody
  • DRP-1 Antibody
  • DRP1 Antibody
  • MGC119312 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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