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Anti-DACH2 Antibody

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产品名称: Anti-DACH2 Antibody
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Anti-DACH2 Antibody


Anti-DACH2 Antibody  的详细介绍
Name: Anti-DACH2 Antibody
See all DACH2 primary antibodies
Description: Goat polyclonal antibody to DACH2.
Applications: ELISA, WB
Reactivity: Mouse
Immunogen: Synthetic peptide corresponding to Human DACH2 (internal region).
Sequence: C-TRKQAVNSSRPGR
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain.
Tissue Specificity: Expressed in embryo, and at lower levels in the newborn.
Sequence Similarities: Belongs to the DACH/dachshund family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 93837 Mouse
  • SwissProt: Q925Q8 Mouse
  • Unigene: 79760 Mouse
    		•
    Synonyms:
  • DACH 2 Antibody
  • DACH2 Antibody
  • DACH2_HUMAN Antibody
  • Dachshund 2 Antibody
  • Dachshund homolog 2 Antibody
  • Dachshund homolog 2 (Drosophila) Antibody
  • Dachshund2 Antibody
  • FLJ31391 Antibody
  • HGNC:16814 Antibody
  • MGC138545 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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