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Anti-DACH1 Antibody

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产品名称: Anti-DACH1 Antibody
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简单介绍

Anti-DACH1 Antibody


Anti-DACH1 Antibody  的详细介绍
Name: Anti-DACH1 Antibody
See all DACH1 primary antibodies
Description: Rabbit polyclonal antibody to DACH1
Specificity: The antibody detects endogenous levels of total DACH1 protein.
Applications: IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human dachshund homolog 1 (Drosophila)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
Tissue Specificity: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
Sequence Similarities: Belongs to the DACH/dachshund family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 1602?Human
  • Omim: 603803?Human
  • SwissProt: Q9UI36?Human
  • Unigene: 129452?Human
    		•
    Synonyms:
  • DACH Antibody
  • DACH1 Antibody
  • DACH1_HUMAN Antibody
  • Dachshund family transcription factor 1 Antibody
  • Dachshund homolog 1 Antibody
  • dachshund homolog 1 (Drosophila) Antibody
  • Dachsund homolog 1 Antibody
  • FLJ10138 Antibody
  • OTTHUMP00000018494 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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