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Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody

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产品名称: Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody
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Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody


Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody  的详细介绍
Name: Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody
See all Cytokeratin 8 primary antibodies
Description: Rabbit polyclonal antibody to Cytokeratin 8 (Acetyl-Lys483)
Specificity: Acetyl-Cytokeratin 8 (K483) Polyclonal Antibody detects endogenous levels of Cytokeratin 8 protein only when acetylated at K483.
Applications: WB, ELISA
Reactivity: Human
Immunogen: Synthesized peptide derived from the human Cytokeratin 8 around the acetylation site of K483.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20˚C / 1 year
Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Involvement in Disease: Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Cellular Location: Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
Database Links:
  • Entrez Gene: 3856 Human
  • Omim: 148060 Human
  • SwissProt: P05787 Human
  • Unigene: 533782 Human
  • Unigene: 708445 Human
    		•
    Synonyms:
  • CARD2 Antibody
  • CK 8 Antibody
  • CK-8 Antibody
  • CK8 Antibody
  • CYK8 Antibody
  • CYKER Antibody
  • Cytokeratin 8 Antibody
  • Cytokeratin endo A Antibody
  • Cytokeratin-8 Antibody
  • DreK8 Antibody
  • EndoA Antibody
  • K2C8 Antibody
  • K2C8_HUMAN Antibody
  • K8 Antibody
  • Keratin 8 Antibody
  • Keratin type II cytoskeletal 8 Antibody
  • Keratin, type II cytoskeletal 8 Antibody
  • Keratin-8 Antibody
  • KO Antibody
  • Krt 2.8 Antibody
  • KRT8 Antibody
  • MGC118110 Antibody
  • MGC174782 Antibody
  • MGC53564 Antibody
  • MGC85764 Antibody
  • sb:cb186 Antibody
  • Type-II keratin Kb8 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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