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Anti-Cytokeratin 18 (phospho-S52) Antibody

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产品名称: Anti-Cytokeratin 18 (phospho-S52) Antibody
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Anti-Cytokeratin 18 (phospho-S52) Antibody


Anti-Cytokeratin 18 (phospho-S52) Antibody  的详细介绍
Name: Anti-Cytokeratin 18 (phospho-S52) Antibody
See all Cytokeratin 18 primary antibodies
Description: Rabbit polyclonal antibody to Cytokeratin 18 (phospho-S52)
Specificity: p-Cytokeratin 18 (S52) pAb detects endogenous levels of Cytokeratin 18 protein only when phosphorylated at Ser52. (removal of the initiator methionine)
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human Cytokeratin 18 around the phosphorylation site of Serine 53.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 46 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue Specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in Disease: Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Cellular Location: Cytoplasm > Perinuclear region. Nucleus > Nucleolus.
Database Links:
  • Entrez Gene: 3875?Human
  • Entrez Gene: 16668?Mouse
  • Entrez Gene: 294853?Rat
  • Omim: 148070?Human
  • SwissProt: P05783?Human
  • SwissProt: P05784?Mouse
  • SwissProt: Q5BJY9?Rat
  • Unigene: 406013?Human
  • Unigene: 22479?Mouse
  • Unigene: 103924?Rat
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    Synonyms:
  • Cell proliferation inducing gene 46 protein Antibody
  • Cell proliferation inducing protein 46 Antibody
  • Cell proliferation-inducing gene 46 protein Antibody
  • CK 18 Antibody
  • CK-18 Antibody
  • CK18 Antibody
  • CYK 18 Antibody
  • CYK18 Antibody
  • Cytokeratin 18 Antibody
  • Cytokeratin endo B Antibody
  • Cytokeratin-18 Antibody
  • K 18 Antibody
  • K18 Antibody
  • K1C18_HUMAN Antibody
  • KA18 Antibody
  • Keratin 18 Antibody
  • Keratin 18, type I Antibody
  • Keratin D Antibody
  • keratin, type I cytoskeletal 18 Antibody
  • Keratin-18 Antibody
  • Krt18 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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