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Anti-Cystatin A (G84) Antibody

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产品名称: Anti-Cystatin A (G84) Antibody
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Anti-Cystatin A (G84) Antibody


Anti-Cystatin A (G84) Antibody  的详细介绍
Name: Anti-Cystatin A (G84) Antibody
See all Cystatin A primary antibodies
Description: Rabbit polyclonal antibody to Cystatin A (G84)
Specificity: Cystatin A (G84) pAb detects endogenous levels of Cystatin A protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human Cystatin A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 11 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
Tissue Specificity: Expressed in the skin throughout the epidermis.
Involvement in Disease: Peeling skin syndrome 4: A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.
Sequence Similarities: Belongs to the cystatin family.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 1475?Human
  • Entrez Gene: 209294?Mouse
  • Entrez Gene: 288075?Rat
  • Omim: 184600?Human
  • SwissProt: P01040?Human
  • SwissProt: P56567?Mouse
  • SwissProt: P01039?Rat
  • Unigene: 518198?Human
  • Unigene: 300592?Mouse
  • Unigene: 78016?Rat
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    Synonyms:
  • AREI Antibody
  • cstA Antibody
  • Cystatin A Antibody
  • Cystatin AS Antibody
  • Cystatin-A Antibody
  • Cystatin-AS Antibody
  • CYTA_HUMAN Antibody
  • Stefin A Antibody
  • Stefin-A Antibody
  • STF1 Antibody
  • STFA Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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