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Anti-CYR61 Antibody

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产品名称: Anti-CYR61 Antibody
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Anti-CYR61 Antibody


Anti-CYR61 Antibody  的详细介绍
Name: Anti-CYR61 Antibody
See all CYR61 primary antibodies
Description: Rabbit polyclonal antibody to CYR61
Specificity: The antibody detects endogenous levels of total CYR61 protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Fusion protein corresponding to a region derived from internal residues of human cysteine-rich, angiogenic inducer, 61
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.6mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Sequence Similarities: Belongs to the CCN family.
Cellular Location: Secreted.
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