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Anti-CYP3A4 Antibody

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产品名称: Anti-CYP3A4 Antibody
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Anti-CYP3A4 Antibody


Anti-CYP3A4 Antibody  的详细介绍
Name: Anti-CYP3A4 Antibody
See all CYP3A4 primary antibodies
Description: Rabbit polyclonal antibody to CYP3A4.
Applications: WB, IHC, FC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:20 - 1:50, FC: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide of human CYP3A4.
Protein Length: 503
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
Tissue Specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
Sequence Similarities: Belongs to the cytochrome P450 family.
Post-Translational Modification: Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).
Cellular Location: Endoplasmic reticulum membrane. Microsome membrane.
Database Links:
  • Entrez Gene: 1576?Human
  • Omim: 124010?Human
  • SwissProt: P08684?Human
  • Unigene: 728751?Human
    		•
    Synonyms:
  • 1,8-cineole 2-exo-monooxygenase Antibody
  • Albendazole monooxygenase Antibody
  • Albendazole sulfoxidase Antibody
  • CP33 Antibody
  • CP34 Antibody
  • CP3A4_HUMAN Antibody
  • CYP3 Antibody
  • CYP3A Antibody
  • CYP3A3 Antibody
  • CYP3A4 Antibody
  • CYPIIIA3 Antibody
  • CYPIIIA4 Antibody
  • Cytochrome P450 3A3 Antibody
  • Cytochrome P450 3A4 Antibody
  • Cytochrome P450 family 3 subfamily A polypeptide 4 Antibody
  • Cytochrome P450 HLp Antibody
  • Cytochrome P450 NF-25 Antibody
  • Cytochrome P450 subfamily IIIA polypeptide 4 Antibody
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 Antibody
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Antibody
  • Cytochrome P450-PCN1 Antibody
  • Glucocorticoid inducible P450 Antibody
  • HLP Antibody
  • MGC126680 Antibody
  • NF 25 Antibody
  • NF25 Antibody
  • Nifedipine oxidase Antibody
  • P450 III steroid inducible Antibody
  • P450 PCN1 Antibody
  • P450, family III Antibody
  • P450C3 Antibody
  • P450PCN1 Antibody
  • Quinine 3 monooxygenase Antibody
  • Quinine 3-monooxygenase Antibody
  • Taurochenodeoxycholate 6 alpha hydroxylase Antibody
  • Taurochenodeoxycholate 6-alpha-hydroxylase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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