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Anti-CYP1A2 Antibody

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产品名称: Anti-CYP1A2 Antibody
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Anti-CYP1A2 Antibody


Anti-CYP1A2 Antibody  的详细介绍
Name: Anti-CYP1A2 Antibody
See all CYP1A2 primary antibodies
Description: Rabbit polyclonal antibody to CYP1A2
Specificity: The antibody detects endogenous levels of total CYP1A2 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human cytochrome P450, family 1, subfamily A, polypeptide 2
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Tissue Specificity: Liver.
Sequence Similarities: Belongs to the cytochrome P450 family.
Cellular Location: Endoplasmic reticulum membrane. Microsome membrane.
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